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Common sequence variants on 20q11.22 confer melanoma susceptibility
- Brown, Kevin M. (author)
- MacGregor, Stuart (author)
- Montgomery, Grant W. (author)
- show more...
- Craig, David W. (author)
- Zhao, Zhen Zhen (author)
- Iyadurai, Kelly (author)
- Henders, Anjali K. (author)
- Homer, Nils (author)
- Campbell, Megan J. (author)
- Stark, Mitchell (author)
- Thomas, Shane (author)
- Schmid, Helen (author)
- Holland, Elizabeth A. (author)
- Gillanders, Elizabeth M. (author)
- Duffy, David L. (author)
- Maskiell, Judith A. (author)
- Ferguson, Megan (author)
- Stephan, Dietrich A. (author)
- Cust, Anne E. (author)
- Whiteman, David (author)
- Green, Adele (author)
- Puig, Susana (author)
- Ghiorzo, Paola (author)
- Hansson, Johan (author)
- Demenais, Florence (author)
- Goldstein, Alisa M. (author)
- Gruis, Nelleke A. (author)
- Elder, David E. (author)
- Bishop, Julia Newton (author)
- Kefford, Richard F. (author)
- Giles, Graham G. (author)
- Armstrong, Bruce K. (author)
- Aitken, Joanne F. (author)
- Hopper, John L. (author)
- Martin, Nicholas G. (author)
- Trent, Jeffrey M. (author)
- Mann, Graham J. (author)
- Hayward, Nicholas K. (author)
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- (creator_code:org_t)
- 2008-05-18
- 2008
- English.
- In: Nature Genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 40:7, s. 838-840
- Journal article (peer-reviewed)
Abstract
Subject headings
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- We conducted a genome-wide association pooling study for cutaneous melanoma and performed validation in samples totaling 2,019 cases and 2,105 controls. Using pooling, we identified a new melanoma risk locus on chromosome 20 (rs910873 and rs1885120), with replication in two further samples (combined P < 1 x 10(-15)). The per allele odds ratio was 1.75 (1.53, 2.01), with evidence for stronger association in early-onset cases.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
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- art (subject category)
- ref (subject category)
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- Henders, Anjali ...
- Homer, Nils
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- Stark, Mitchell
- Thomas, Shane
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- Duffy, David L.
- Maskiell, Judith ...
- Jetann, Jodie
- Ferguson, Megan
- Stephan, Dietric ...
- Cust, Anne E.
- Whiteman, David
- Green, Adele
- Olsson, Håkan
- Puig, Susana
- Ghiorzo, Paola
- Hansson, Johan
- Demenais, Floren ...
- Goldstein, Alisa ...
- Gruis, Nelleke A ...
- Elder, David E.
- Bishop, Julia Ne ...
- Kefford, Richard ...
- Giles, Graham G.
- Armstrong, Bruce ...
- Aitken, Joanne F ...
- Hopper, John L.
- Martin, Nicholas ...
- Trent, Jeffrey M ...
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- MEDICAL AND HEALTH SCIENCES
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- Nature Genetics
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- Lund University
- Karolinska Institutet
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